Comparison of bronchalveolar-lavage enzyme-linkend immunospot and PCR for the diagnosis of smear-negative tuberculosis: interim analysis of a TBNET study
C Jafari, A Bossink, D Goletti, L Codecasa, A Strassburg, U Greinert, B Kalsdorf, D Kirtsen, A Lalvani, M Ernst, C Lange · Pneumologie · 2008 · Heft 04
Bibliografische Angaben
Zusammenfassung
Background: The diagnosis of active pulmonary tuberculosis (pTB) in patients with negative acid-fast-bacilli (AFB) smear results from sputum and bronchial secretions is often delayed. We present an interim analysis of an ongoing study of the European Tuberculosis Network (TBNET) on the comparison of a Mycobacterium tuberculosis (MTB) specific ELISPOT performed on mononuclear cells from the bronchoalveolar-lavage (BALMCs) and MTB- specific polymerase chain reaction (PCR) for the rapid diagnosis of smear negative pTB. Methods: Following informed consent, patients with a medical history and a pulmonary infiltrate c…
