Loss of LH/HCG Receptor Expression in Invasive Breast Cancer Tissure compared to preinvasive Component

Objective: LH/human chorionic gonadotropin (hCG) receptors are present in a variety of nongonadal tissues including normal breast as well as breast cancer tissue. In vitro studies and animal studies, respectively, have demonstrated that hCG inhibits the initiation and progression of experimental breast carcinoma. According to these observations it seems that LH/hCG recptor could be a target for prevention and therapy of breast carcinoma. We therefore investigated the LH/hCG receptor expression of preinvasive and invasive breast cancer as well as phylloides tumor specimen on tissue microarrays. Design and Method:…