Ileitis terminalis (CD) and leiomyosarcoma: among the firsts discovered in vivo and preoperatively. case report and literature review upon possible common pathomechanism

Introduction: The smooth muscle tumours, like in the presented Crohn (CD) patient, are the second most frequent mesenchymal neoplasms – after GIST – in the gastrointestinal tract. Chronic inflammations – as CD – in general have a regeneration generating affect. Recently showed in IBD high εdC/εdA ratio, that leeds to adaptive, but unbalanced DNA repair mechanism responsible for MSI (microsatellite instab.) Aim: To discuss how far can we get back to Virchow in the mirror of some new theories (reactiv oxygen and nitroso substances vs. antioxydants) and diagnostic methods (urine test of εdC, εdA ethenonucleotides)?…