Beneficial effect of bortezomib pre-treatment on cholecystokinin-octapeptide-(CCK-8)-induced experimental pancreatitis

The proteosome inhibitor bortezomib is used in the treatment of patients with myeloma multiplex. Proteosomes are responsible for the degradation of I-κB, the inhibitory protein of the inflammatory transcription factor nuclear factor kappa B (Nf-κB). The heat shock protein (HSP) inducing effect of bortezomib is also documented. The role of Nf-κB and HSP72 in the development of acute pancreatitis is well known. The Aim of our work was to test the anti-inflammatory effect of bortezomib in CCK-8-induced acute pancreatitis. Methods: Male Wistar rats weighing 230–250g were divided into three groups (n=8 in each). Rats…