Septin 9 methylation as a plasma biomarker for blood based screening of colorectal cancer

Background: The colorectal cancer is one of the leading cause of death worldwide. The present screening tests do not have respective specificity and sensitivity; furthermore the compliance is very low. The DNA methylation can take part in the early carcinogenesis. Its detection is possible from both biopsy and peripheral blood samples. The differences between carcinoma and normal samples can be detected with the identification of methylated sequence. Aim: Our aim was to give an overview about septin 9 sensitive methylation marker verification and confirmation from the peripheral blood of colorectal cancer patien…