Evidence of an association between the adenylate kinase genetic polymorphism and primary repeated spontaneous abortion

A recent study of healthy pueperae suggests that the adenylate kinase locus 1 (Ak1) genetic polymorphism may be involved in intrauterine selection. This prompted us to search for a possible relationship between this polymorphism and primary repeated spontaneous abortion. Ak1 catalizes the reaction ATP+AMP 2ADP, and has an important role in the synthesis of nucleotides involved in several metabolic functions as well as in DNA and RNA synthesis. Methods: The study samples included 178 Caucasian women with primary Repeated Spontaneous Abortion (RSA) and their husbabds from the population of Rome, 98 healthy Caucasi…