Vemurafenib effectively controlled Chemotherapy-refractory Intrahepatic Cholangiocarcinoma with BRAF V600E Mutation: a case report and literature review
Mengyuan Yang, Liuhong Wang, Ying Yuan · Zeitschrift für Gastroenterologie · 2022 · Heft 12 · S. 1787-1791
Bibliografische Angaben
Zusammenfassung
Abstract Background Chemotherapy is the first treatment option for local advanced or metastatic intrahepatic cholangiocarcinoma (ICC). However, after first-line chemotherapy, there is no standard second-line treatment or targeted agents for these patients. Case presentation Here we present an advanced ICC patient who has received radical resection and adjuvant chemotherapy (gemcitabine + cisplatin). But the no evidence of disease (NED) was maintained for only 6 months after the end of chemotherapy. He then received palliative surgery, radiotherapy and systemic chemotherapy (Tegafur+Oxaliplatin (SOX) and Nab-Pacl…