Low-dosed botulinum toxin in migraine without aura: A randomized, double-blind placebo-controlled crossover study

Botulinum toxin is a therapeutic option in chronic migraine. Dose-finding studies have not been conducted so far. Some authors reported that one injection in the corrugator muscle would do. Issue: We studied the effect of botulinum toxin (BTX) injections in patients with strictly unilateral migraine. Patients and Methods: 22 patients (ITT) were treated in a crossover design for 4 months with 2×5 units Botox® (injected in the corrugator muscle and next to occipitalis major nerv ipsilaterally). Aside from patient data and ADR (adverse drug reactions), we registered IQOLA SF36, SF-MQ SADP, OLBPDQ, VAS (intensity of…