Role of cathepsin G and neutrophil elastase in the lung host defense against mycobacterial infections
K Steinwede, K Walter, S Aly, J Bohling, R Maus, O Schreiber, M Srivastava, F Länger, T Welte, S Ehlers, UA Maus · Pneumologie · 2010 · Heft 03
Bibliografische Angaben
Zusammenfassung
Background: Tuberculosis remains to be a major health threat with ˜ 8–10 million new infections and 2–3 million deaths per year worldwide. The current study aimed at elucidating the role of neutral serine proteases cathepsin G and neutrophil elastase in the lung host defense against mycobacterial infections. Methods and Results: We found that cathepsin G deficient mice responded with a significantly decreased survival and significantly impaired pathogen elimination to infection with either M. tuberculosis or M. bovis BCG. Moreover, an even more accentuated disturbation of the pathogen elimination process was obs…
