DNA methylation profile in colorectal cancer versus normal colonic tissue – preliminary results
VA Patai, O Galamb, K Tóth, A Kalmár, S Spisák, B Wichmann, O Jász, K Leiszter, G Valcz, F Sipos, A Schöller, Z Tulassay, B Molnár · Zeitschrift für Gastroenterologie · 2010 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: DNA methylation in the promoter region of tumor suppressor genes is a common epigenetic silencing mechanism and has been proved to be a crucial mechanism in colorectal carcinogenesis. To our knowledge, no studies have been performed so far analyzing DNA methylation profile of colorectal cancer (CRC) in both serum and tissue samples from matched patients. Aim: To find DNA methylation markers that appear both in biopsy tissue and in plasma and accordingly determine a set of DNA methylation markers that could be used as a diagnostic tool to detect CRC at an early stage. Method: At the present stage of o…
