Efficacy of temoporfin photodynamic therapy (PDT) for bile duct cancer
GW Wolkersdörfer, K Emmanuel, U Denzer, A Puespoek, D Neureiter, T Kiesslich, AW Lohse, F Berr · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aim: At present local ablation using porfimer and laser irradiation (632nm) of tumour stenoses is most effective in palliation of hilar bile duct cancer (BDC). However, the tumoricidal effect is confined to inner 4mm of the tumour wall (6–9mm) resulting in overall median suvival between 9 and 21 months. We have studied efficacy of temoporfin-based PDT (T-PDT, 652nm) with twice as deep tumoricidal tissue penetration in these patients (EUDRACT Nr.2005–004866–17). Methods: 18 patients (9:9 f/m; age 68 [47–88] yrs) with hilar BDC were treated with T-PDT. In two of them T-PDT was performed in a neoadjuvant manner. Re…
