Adefovir treatment failure is not associated with low serum drug levels
K Deterding, L Naesens, M Buti, H Janssen, J Kirschner, A Guerrero, J Reijnders, J Neyts, F Zoulim, H Wedemeyer · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: Primary or secondary failure of adefovir dipivoxil therapy of chronic hepatitis B is not infrequent. The reasons for suboptimal responses are not well defined. In HIV and HCV infection, failure of antiviral drug administration has been linked with low blood drug levels. Methods: We have studied 20 well defined patients for adefovir drug kinetics. Three centers included 20 patients treated with Adefovir; 10 patients with secondary treatment failure or suboptimal primary response and 10 patients with response to Adefovir treatment. The kinetic study was done at the time point of the first diagnosis o…
