Therapy response in chronic hepatitis C patients is affected by common Vitamin D Receptor (NR 1I1) polymorphisms
K Baur, JC Mertens, J Schmitt, R Iwata, B Stieger, P Frei, J Braun, B Müllhaupt, A Geier · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background and aims: Chronic hepatitis C virus (HCV) infection represents a leading cause of end stage liver disease worldwide. Non-parenchymal hepatic cells as mediators of inflammation and fibrogenesis such as sinusoidal endothelial cells, Kupffer cells and hepatic stellate cells do express VDR mRNA and functionally active VDR protein. Given the established role of vitamin D as an immunomodulator it is straightforward to investigate a potential effect of common polymorphisms in the VDR (NR1I1) gene on hepatic inflammation and therapy response. Methods: Overall, 166 patients with available blood samples and liv…
