The combined influence of low serum Insulin-Like Growth Factor I and low total testosterone on all-cause mortality in adult men

Background: Lower levels of anabolic hormones in older age are well documented. Several studies have suggested that low serum levels of like insulin-like growth factor I (IGF-I) or total testosterone in men were related to higher morbidity and mortality. The aim of the present study was to investigate the combined influence of low IGF-I and low total testosterone levels on mortality in adult men. Methods: From two German prospective cohort studies, the DETECT study and SHIP, 4,092 men aged 18–91 years were available for the analyses. Low levels of serum IGF-I and total testosterone levels were defined as values…