A new model of synergistic effects of alcohol and high-fat diet on hepatic injury

Background: Alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH) are the frequent conditions leading to elevated liver enzymes and liver cirrhosis, in the Western World. Despite strong epidemiological evidence for combined effects on the progression of liver injury the mutual interaction of the pathophysiological mechanisms is incompletely understood. Aim and methods: The aim of this study was to establish and analyze an experimental murine model, where we combined chronic alcohol administration in drinking water (increasing concentrations up to 5%) with a non-alcoholic steatohepatitis (NASH)…