BrainAGE Scores Derived from Structural MRI Predict Conversion from MCI to AD

Purpose: For Alzheimer's disease (AD), it may be possible to identify biomarkers that can predict probable development of AD before the onset of cognitive decline or clinical symptoms. Current studies showed limitations in differentiating subjects with mild cognitive impairment (MCI) who would not show future cognitive decline from those who will progress to AD within a certain time span. We investigated the potential of our fast and fully automatic age estimation framework based on MRI data to contribute to an early indication of those MCI subjects who will progress to AD within the next two years. Materials an…