CareLit Fachartikel
Modulation of intracellular TGF-beta signalling by different PDGF isoforms and MEK1/2 in a murine hepatic stellate cell line
P Alexi, R Weiskirchen · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Dokument
866183
CareLit-ID
Jahr
2011
Publikation
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DOI
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Zusammenfassung
Background: TGF-β signalling plays an important, pro-fibrogenic role in liver fibrogenesis [1]. In addition it is known that the biological sequestering of platelet-derived growth factor (PDGF)-BB and PDGF-DD abrogates fibrogenic attributes in culture-activated hepatic stellate cells and in models of experimental hepatic fibrogenesis [2, 3]. Several previous reports further suggested that members of the PDGF family are prominent modulators of pro-fibrogenic TGF-β signalling in many cell systems. Methods: In the current study, we have tested the impact of different PDGF isoforms (PDGF-AA, PDGF-BB, PDGF-CC, PDGF-D…
Schlagworte
GRX
PDGF
TGF-beta
collagen type I
costimulation
reporter assay
Zeitschrift für Gastroenterologie
