CareLit Fachartikel
The novel endocannabinoid virodhamine selectively induces cell death in hepatic stellate cells but not in hepatocytes
A Wojtalla, F Herweck, MV Singer, A Zimmer, SV Siegmund · Zeitschrift für Gastroenterologie · 2011 · Heft 01
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866189
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Jahr
2011
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Zusammenfassung
Aims: We have previously shown that the endogenous cannabinoid anandamide (N-arachidonoyl ethanolamide, AEA) is an antifibrotic lipid mediator that blocks proliferation and induces cell death in hepatic stellate cells (HSCs), but not in hepatocytes. However, the effects on hepatic cell populations of the novel endocannabinoid virodhamine (O-arachidonoyl ethanolamine), whose tissue levels exceed those of AEA >9 times, has not been investigated so far. Methods: Primary rat hepatocytes and HSCs were isolated by collagenase perfusion. AEA- and virodhamine-induced cell death was analysed by LDH assay and annexin V/pr…
Schlagworte
Hepatic stellate cells
antifibrotic
cell death
endocannabinoids
hepatocytes
virodhamine
Zeitschrift für Gastroenterologie
