microRNA profile changes match with proteome analysis during liver regeneration after rat partial hepatectomy

Introduction: The liver has the unique capacity to regenerate after surgical resection. However, the mechanisms of liver regeneration are not completely understood. Small non-coding microRNAs (miRNAs) have been shown play a critical role in regulation of hepatocyte proliferation during carcinogenesis, development and early regeneration. We hypothesized that miRNAs are involved in all phases of regeneration after liver resection. Methods: We performed miRNA microarray analyses after 70% partial hepatectomy in Wistar rats (n=3) at six different time points (0, 2, 6, 12, 24, 48 hours, and 5 days). Putative targets…