A method for automated volumetry to assess disease progression in Rasmussen Encephalitis

Introduction: Rasmussen Encephalitis (RE) is a chronic inflammatory disease of the brain that affects and subsequently destroys one hemisphere and is causing intractable seizures and progressive neurologic deficits. Manual planimetric volumetry based on single slices of MRI-studies has been performed before, resulting in a number of indices to assess disease progression of which the hemispheric ratio proved to be the most valuable. We have applied a novel automated volumetric approach to assess disease progression in Rasmussen Encephalitis. Methods: Structural MRI was performed on a 3T scanner (Siemens Magnetom…