SGK1: a novel prognostic marker and potential drug target in medulloblastoma
S Pleier, D Sturm, M Remke, H Witt, V Goidts, G Reifenberger, J Felsberg, AE Kulozik, A Korshunov, P Lichter, SM Pfister · Klinische Pädiatrie · 2011 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: Based on an integrative genomics approach using array-CGH, genome-wide mRNA expression profiling, and immunohistochemistry, we identified Serum- and glucocorticoid-inducible kinase (SGK1) as a novel prognostic marker in medulloblastoma (MB). SGK1 encodes a kinase with high sequence- and structural homology to the anti-apoptotic kinase AKT1. To reduce peri-tumoral edema, glucocorticoids (GC) are frequently used peri-operatively in the management of MB. Although recent data suggest induction of chemotherapy-resistance by GC in solid tumors due to protection from apoptosis mediated by SGK1 (Herr, Buch…
