Testis Atrophy and Hypogonadism in ApoE-/-/LDL-/- double knockout Mice
AC Langheinrich, R Kilinski, A Paradowska, B Altinkilic, K Steger, P Stieger, M Bergmann, W Weidner · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2011 · Heft 04
Bibliografische Angaben
Zusammenfassung
Ziele: Aging and atherogenesis are seemingly inseparably linked. Age related decline of testosterone levels is referred to as andropause, hypogonadism and declining testicular function, but its relation to atherosclerosis is not yet defined. Therefore, we investigated testicular morphology in apoE-/-/LDL-/- double knockout mice. Methode: Testes from apoE-/-/LDL-/- double knockout mice at the age of 80 weeks (n=8) were in-vivo perfused with contrast agent, harvested and scanned with micro-CT at (4.9µm)3 voxel size. Testes of C57/BL mice at the age of 72 weeks served as controls (n=10). Testis volume (mm3) and tot…