Chemokine presentation by liver sinusoidal endothelial cells as therapeutic target in murine T cell-mediated hepatitis
K Neumann, N Kruse, K Wechsung, M Schumann, A Kühl, U Erben, M Zeitz, K Klugewitz · Zeitschrift für Gastroenterologie · 2011 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background & aims: Leukocyte adhesion and transmigration is one of the central paradigms of inflammation. Within the liver sinusoids, chemokines initiate the first crucial step of lymphocyte migration into the parenchyma. Particularly liver sinusoidal endothelial cells (LSEC) present chemokines increasing their biological activity. We here investigated mechanisms of chemokine transport by LSEC and whether inhibition of endothelial chemokine presentation influences autoimmune hepatitis. Methods: In the model of Concanavalin (Con) A-induced T-cell mediated hepatitis chemokine expression was determined. Chemokine u…
