Human intestinal and systemic adaptation of iron metabolism and transport to hypoxia in healthy mountaineers after rapid ascent to 4559m
O Goetze, J Schmitt, K Spliethoff, H Fruehauf, K Wojtal, M Maggiorini, T Lutz, A Geier · Zeitschrift für Gastroenterologie · 2011 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background & aims: Human iron metabolism is closely regulated by erythropoesis, oxygen homeostasis and intestinal iron absorption. The aim of this study was to characterize for the first time the adaptation of iron metabolism and transport to hypoxia under high altitude conditions in man at the levels of (i) intestinal iron uptake (ii) changes in systemic iron homeostasis and hemoglobin in one comprehensive overview. Methods: 28 mountaineers (10M/18 F, 44.0±2.6 y., BMI 23.7±0.6kg/m2) were studied. Duodenal biopsies were taken by unsedated nasal endoscopy from each volunteer at 490m in Zurich [ZH] at baseline and…
