Armed oncolytic measles vaccine virus – a novel therapeutic agent for virotherapy of solid tumors
S Berchtold, J Lampe, T Weiland, S Schleicher, R Handgretinger, HG Kopp, J Reiser, F Stubenrauch, M Bitzer, UM Lauer · Zeitschrift für Gastroenterologie · 2011 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: The oncolytic potential of measles vaccine virus (MeV) has been demonstrated in several tumor models but it has also been shown that primary and secondary resistances exist or may arise. To improve the oncolytic potential of MeV and to overcome resistances, a transgene armed measles vaccine virus was generated (MeV ld-SCD). A suicide gene (SCD) was inserted encoding a fusion protein consisting of the enzymes yeast cytosine deaminase and yeast uracil phosphoribosyltransferase. This allows the systemic application of the prodrug 5-fluorocytosine (5-FC) which is locally converted into the chemotherape…
