CareLit Fachartikel
CD20+ B cell infiltration in a mouse model for HBV-associated liver fibrosis depends on genetic background
J Stiefel, Y Churin, M Roderfeld, K Kopsch, D Glebe, E Roeb · Zeitschrift für Gastroenterologie · 2011 · Heft 08
Dokument
866987
CareLit-ID
Jahr
2011
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ja
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Zusammenfassung
Introduction: Chronic hepatitis B virus (HBV) infection is associated with acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Mouse models that mimic many of the pathological events of HBV mediated liver fibrosis are yet not well understood. We examined transgenic (tg) mice which overproduce the HBV large envelope polypeptide for liver fibrosis with different genetic background – C57BL/6 and BALB/c. Since the impact of B-cells could be demonstrated in a CCl4-induced model of fibrosis1 our aim was to analyse B cells in the liver of HBV-transgenic mice. Methods: C57BL/6 versus BALB/c transgenic…
Schlagworte
Hepatitis
Alanine Transaminase
B-Lymphocytes
Alanine
After
Zeitschrift für Gastroenterologie
