Expression of the embryonic stem cell marker SOX2 in breast carcinoma
T Fehm, R Kurth, C Lengerke, PM Bareiss, V Scheble, F Müller, F Schneider, D Wallwiener, L Kanz, F Fend, S Perner, A Staebler, H Neubauer · Geburtshilfe und Frauenheilkunde · 2011 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: Cancer stem cells (CSC) or cancer initiating cells (CIC) are tumor cells capable of initiation and propagation of the malignant disease. More recently, SOX2 was shown to participate in reprogramming of adult somatic cells to a pluripotent stem cell state and was implicated in tumorigenesis in various organs. In this study, expression of SOX2 in primary breast carcinomas is characterized by an integrated and interdisciplinary approach. Methods: Paraffin embedded tissue of a series of 95 cases of postmenopausal breast carcinomas was analyzed by immunohistochemistry for SOX2 expression. SOX2 amplification sta…
