CareLit Fachartikel

Genes involved in epithelial-mesenchymal transition in carcinomas may also play a role in migration and invasion of human glioblastoma cells

CD Kühnöl, C Würfel, MS Staege, CM Kramm · Klinische Pädiatrie · 2011 · Heft 11

Dokument
867093
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
CD Kühnöl, C Würfel, MS Staege, CM Kramm
Ausgabe
Heft 11 / 2011
Seiten
–
Erschienen: 2011-11-03 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0031-1292591

Zusammenfassung

Introduction: Epithelial-mesenchymal transition (EMT) is an important mechanism of carcinomas in change over from local tumours into infiltrating and metastasing tumours. EMT is hallmarked by key genes (e.g. SNAI1) that were partially also found in human glioblastomas (hGBM). The high potential of human glioblastoma cells to migrate and infiltrate essentially contributes to the overall poor prognosis by circumvention of effective local treatment strategies. The coherence of these key genes with tumour biological functions in glioblastomas is not yet determined. Here we describe in vitro analyses of the influence…

Schlagworte

Snai1 Human Glioblastoma Lines Cells Migration Glioblastomas Analyses Proliferation Genes Invasion Over-Expression Klinische Pädiatrie