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Targeted Gene Arrays across the Severely-Discordant growth Monochorionic Twin Placenta: Implications for Angiogenesis and Metabolic Programming

S Schrey, D Baczyk, B Fitzgerald, G Ryan, J Kingdom, S Drewlo · Zeitschrift für Geburtshilfe und Neonatologie · 2011 · Heft 11

Dokument
867124
CareLit-ID
Jahr
2011
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Geburtshilfe und Neonatologie
Autor:innen
S Schrey, D Baczyk, B Fitzgerald, G Ryan, J Kingdom, S Drewlo
Ausgabe
Heft 11 / 2011
Seiten
–
Erschienen: 2011-11-17 00:00:00
ISSN
0948-2393
DOI
10.1055/s-0031-1293261

Zusammenfassung

Ziel: To explore angiogenesis and metabolic gene expression pathways in severe discordant monochorionic (MC) IUGR that may be subject to epigenetic regulation. Methodik: We studied 10 severely growth-discordant twins (birth weight difference ≥ 25%) without twin-twin-transfusion syndrome (TTTS). Growth discordant twin placentas were phenotyped by histology, demonstrating distal villous hypoplasia or immaturity on the IUGR side. Two random and unbiased snap frozen placental samples were collected at time of delivery from each twin. Placental mRNA expression of 88 angiogenesis related genes were measured by PCR arr…

Schlagworte

Discordant growth monochorionic twin angiogenesis epigenetic regulation placental growth factors Leptin Expression Discordant Epigenetic Twins Genes Metabolic Regulation Syndrome Villous Placental Zeitschrift für Geburtshilfe und Neonatologie