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The therapeutic effect of betamethasone for prenatal lung maturation in very low birthweight infants may be influenced by maternal and fetal ABCB1-polymorphism – A pilot study

G Kewitz, I Roots · Zeitschrift für Geburtshilfe und Neonatologie · 2011 · Heft 11

Dokument
867137
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Jahr
2011
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Geburtshilfe und Neonatologie
Autor:innen
G Kewitz, I Roots
Ausgabe
Heft 11 / 2011
Seiten
–
Erschienen: 2011-11-17 00:00:00
ISSN
0948-2393
DOI
10.1055/s-0031-1293391

Zusammenfassung

Ziel: A retrospective pilot study was performed as a preparation for a prospective one planed to prove the hypothesis addressed in the title. Methodik: In a cohort of 183 preterm infants consecutively delivered before 28 weeks gestation in our perinatal center level I we identified 10 infants from 8 mothers who fulfilled the following criteria: caucasian, eutroph, betamethasone treatment for lung maturation completed, intrauterine infection excluded by blood analyses and placenta histology, fluids clear, no malformation or severe disease or complication. Infants fulfilling criteria for the diagnosis of surfactan…

Schlagworte

ABCB1-polymorphism MDR P-glycoprotein betamethasone blood-placenta barrier fetal therapy lung maturation preterm transporter gene very low birthweight infant Blood Ventilation Diagnosis Allele After Zeitschrift für Geburtshilfe und Neonatologie