CareLit Fachartikel
BMP6 protects against hepatic inflammation and fibrosis in experimental NASH models
S Arndt, E Wacker, M Saugspier, C Dorn, C Hellerbrand, A Bosserhoff · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
867177
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
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Zusammenfassung
Background & Aims: Nonalcoholic fatty liver disease (NAFLD) starts with hepatic steatosis, which can progress with inflammation to non-alcoholic steatohepatitis (NASH), and a subset of patients develop fibrosis, which may progress to cirrhosis. Different studies have uncovered bone morphogenetic proteins (BMPs) as important molecules being involved in organ fibrosis, however, studies regarding hepatic fibrosis are sparse and mostly focused on BMP7, of which anti-fibrogenic effects have been described.The aim of this study was to analyze the expression and function of BMP6 in NAFLD. Methods and Results: BMP6 defi…
Schlagworte
BMP6
NASH
mouse model of NAFLD
Diet
Choline
Zeitschrift für Gastroenterologie
