IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice
H Weng, S Radaeva, D Feng, Y Gao, Y Liu, Q Li, H Shen, R Müllenbach, T Huang, JL Chen, V Zimmer, F Lammert, PR Mertens, S Zakhari, WM Cai, S Dooley, B Gao · Zeitschrift für Gastroenterologie · 2012 · Heft 01
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Zusammenfassung
Aims: Hepatic progenitor cells (HPCs) are crucial in hepatic regeneration and liver remodelling. A correlation of HPC activation during periportal fibrosis in HCV- and NASH-associated liver diseases suggests a role in fibrogenesis. IFN-γ is well recognized as fibrotic inhibitor and also may participate in regulation of HPC activation, although current results are controversial. To get further insight, we studied HPC activation in HBV infected patients and 3,5-diethoxycarbonyl–1,4-dihydrocollidine (DDC) treated mice. Methods: Human HPCs and mouse oval cells (HPCs in rodents) were quantified by cytokeratin–19 (CK1…
