Ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE) Generates Hepatoprotective conjugated UDCA, Phosphatidylcholine, Medium-chain Fatty acids and Plasmalogen 16: 1
W Chamulitrat, W Xu, A Pathil-Warth, G Liebisch, G Schmitz, W Zhang, K Setchell, W Stremmel · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: We have shown that UDCA-LPE elicits protection by activating survival signalling pathways, and inhibits TNFα-induced apoptosis in vitro and inflammation in vivo when intraperitoneally (i.p) injected to galactosamine/endotoxin-treated mice. UDCA and phosphatidylcholine (PC) are known hepatoprotectants via membrane stabilization. We tested herein whether UDCA-LPE undergoes hydrolysis to UDCA and LPE, and whether it increases cellular UDCA, PC and other cytoprotective lipids. Methods: UDCA-LPE was used to treat mouse hepatocytes at 40–60µM or i.p injected to mice at 30mg/kg. Fatty acid analyses were p…
