CareLit Fachartikel
Towards unravelling the molecular mechanisms of human hepatocyte steatosis in situ
L Pawella, B Straub, M Hashani, P Schirmacher · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
867186
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Hepatocellular steatosis is one of the most common liver pathologies in western countries, and is characterized by lipid droplet (LD) accumulation in hepatocytes. Members of the PAT-protein family (perilipin, adipophilin, TIP47;=PERILIPIN 1–3) mainly govern the LD-surface. Interestingly, perilipin A, the major LD-associated protein in mature adipocytes, could be detected in human steatotic hepatocytes as well. Yet, the transcriptional basis of PAT-expression in hepatocyte steatogenesis has not been finally clarified. In this study, we measured the triacylglyceride (TAG) content of over 30 human livers and analyz…
Schlagworte
Hepatocyte Steatosis
PAT-protein
Steatogensis
Adipogenesis
Adipophilin
Adipocytes
Zeitschrift für Gastroenterologie
