Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients
P Frei, AK Leucht, U Held, R Kofmehl, M Rau, J Schmitt, T Gerlach, F Negro, M Heim, D Moradpour, A Cerny, JF Dufour, B Müllhaupt, A Geier · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Age is frequently discussed as negative host factor to achieve a sustained virological response (SVR) to antiviral hepatitis C therapy. However, elderly patients often show relevant fibrosis as known negative predictive factor, making it difficult to interpret age as an independent predictive factor. Methods: We analyzed data on hepatitis C therapy with PEG-interferon and ribavirin in 516 patients including 66 elderly patients ≥ 60 years. We analyzed host factors (age, gender, fibrosis, haemoglobin, depression, earlier hepatitis C treatment), viral factors (genotype, viral load) and treatment course. Gener…
