Serum sodium based modification of the MELD score does not improve the predictive value in acute liver failure

Aims: The MELD score, initially established to predict survival following TIPSS procedure has been utilized as a prognostic tool in ALF since 2007. Inclusion of serum Na+ into the MELD score was found to improve its predictive value in cirrhotic patients, as hyponatremia is associated with a worse prognosis. Aim of this study was to determine whether inclusion of serum Na+ improves the predictive value of MELD in ALF of diverse etiologies compared to established criteria. Methods: In a prospective single center study (11/2006–12/2010), 127 consecutive ALF patients were recruited. Clinical and laboratory data wer…