HDV LACKING HBV CAN INFECT HUMAN HEPATOCYTES IN THE LIVER OF CHIMERIC uPA/SCID MICE AND PERSIST FOR AT LEAST SIX WEEKS BEFORE BEING RESCUED BY SUPERINFECTION WITH HBV
M Helbig, M Lütgehetmann, T Volz, L Allweiss, AW Lohse, J Petersen, J Taylor, M Dandri · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: HDV replication leads to RNA-editing, accumulation of the large HDAg,down-regulation of RNA accumulation and appearance of non-infectious HDV RNAs.However, clinical studies show that HDV can replicate at high levels in infected humansfor years in the setting of low HBV replication. Aim of this study was to determinewhether HDV replication and accumulation can persist in the absence of HBV andwhether infectious HDV can be rescued by super-infection with HBV. Methods: HDV,lacking HBV, was assembled in transfected cells, concentrated, and used to infect 9human chimeric uPA/SCID mice (50μl at 10E8 copies/ml pe…
