HEV-specific T-cell responses are associated with control of HEV infection
PV Suneetha, S Pischke, V Schlaphoff, J Grabowski, P Fytili, A Gronert, B Bremer, A Markova, J Jaroszewicz, CL Bara, MP Manns, M Cornberg, H Wedemeyer · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Hepatitis E virus (HEV) infection is usually self-limited limited but may lead to acute hepatitis and rarely to fulminant hepatic failure. Persistent HEV infections have recently been described in organ transplant recipients receiving immunosuppressive medications suggesting that HEV is controlled by adaptive immune responses. However, only few studies did investigate HEV-specific T-cell responses and immune correlates for the failure to clear HEV infection have not been established so far. We investigated T-cell responses against HEV in 38 subjects including anti-HEV-positive (exposed, n=9) and anti-HEV-negativ…
