Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics

Introduction: No standard curative therapy is available for peritoneal carcinosis often caused by gastrointestinal, but also by hepatobiliary tumors. A novel strategy to kill the cancer cells within the peritoneal cavity could be the use of virotherapeutics combined with the surgical method of peritonectomy. JX–594, an oncolytic poxvirus, already demonstrated antitumoral activities in patients with primary or metastatic liver cancer. The oncolytic Vaccinia virus GLV–1h68 already revealed its ability to reduce the cell mass of solid tumors of several cancer species in human xenograft models and is currently teste…