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Imaging and profiling lung fibroblasts in 3D cell culture models

G Burgstaller, M Kronberger, B Oehrle, O Eickelberg · Pneumologie · 2011 · Heft 12

Dokument
867208
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
G Burgstaller, M Kronberger, B Oehrle, O Eickelberg
Ausgabe
Heft 12 / 2011
Seiten
–
Erschienen: 2011-12-05 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0031-1296101

Zusammenfassung

Introduction: In conventional 2D monolayer cell culture systems cell-matrix adhesions are well known and studied protein aggregations with functions in cell-adhesion, mechanotransduction, cell-signaling, invasion and migration. However, to date little is known about focal adhesion formation in mesenchymal cells growing in 3D cell culture environments and in vivo, where cells are completely embedded in an extracellular matrix. 3D cell culture models more closely resemble the physiological in vivo condition. Currently, it is a hot debate and ongoing controversy whether cells in such a 3D matrix would form adhesion…

Schlagworte

Culture Models Migration Fibroblasts Collagen Adhesions Focal Ccl206 Imaging Invasion Cells Embedded Pneumologie