CareLit Fachartikel
Carbon nanotube instillation in mice causes sustained pulmonary inflammation and apoptosis of alveolar macrophages
NC Habel, S Hirn, F Tian, O Eickelberg, T Stoeger · Pneumologie · 2011 · Heft 12
Dokument
867209
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Jahr
2011
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Zusammenfassung
Introduction: Inhalation of nanoparticles has been associated with acute and chronic pulmonary inflammation. The underlying pathways however are mostly unknown. Due to their phagocytic activity, alveolar macrophages (AM) are considered to play an important role in triggering the toxicological response to inhaled particles. Results: Here, we show that a single exposure of mice to fibrous carbon nanotubes (CNT) but not isometric carbon nanoparticles (CNP) induces sustained lung inflammation and cell death of AM until day 90 post instillation. Although lavage analysis revealed increasing CCL2 levels and macrophage…
Schlagworte
Caspase 3
Caspase 9
After
Apoptosis
fas Receptor
Caspase 8
Pneumologie
