CareLit Fachartikel

Role of Surfactant Proteins in the interaction of nanoparticles with the air-blood-barrier

CA Ruge, UF Schäfer, J Kirch, M Schneider, O Cañadas, J Perez-Gil, C Casals, CM Lehr · Pneumologie · 2011 · Heft 12

Dokument
867212
CareLit-ID
Jahr
2011
Publikation
PDF
nein
Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
CA Ruge, UF Schäfer, J Kirch, M Schneider, O Cañadas, J Perez-Gil, C Casals, CM Lehr
Ausgabe
Heft 12 / 2011
Seiten
–
Erschienen: 2011-12-05 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0031-1296141

Zusammenfassung

Purpose: Pulmonary surfactant (PS) is the first biological matter a nanoparticle (NP) encounters after deposition into the alveolar lumen. This complex mixture of lipids and proteins offers a pool of biomolecules that can undergo bio-nano-interactions. Especially adsorption of the prevailing Surfactant Protein A (SP-A) might lead a NP – protein corona, that probably largely influences further biological effects like translocation or clearance. Therefore we studied the binding of this protein to magnetic NPs (mNPs) coated with different inhalation relevant materials and the impact of this effect on alveolar macro…

Schlagworte

Adsorption After Densitometry Lead Blood Pneumologie