Cortical and subcortical connectivity during hand movements at different frequencies

Aims: Motor actions result from an interplay of various brain regions engaged in different aspects of movement preparation and execution. Functional imaging studies have shown that increasing the speed of a movement is associated with higher blood oxygen level dependent (BOLD) responses within the contralateral sensorimotor cortex1. It is, however, not known which areas drive these increases in neural activity. Therefore, we investigated the effective connectivity during paced fist closure at different frequencies to identify the motor regions that are involved in frequency-dependent hand movements. Methods: Twe…