A metabolic topology of cognitive ageing, Parkinson's disease and dementia

Introduction: Parkinson’s disease with and without dementia (PDD and PD), dementia with Lewy-bodies (DLB), mild cognitive impairment (MCI) and Alzheimer dementia (AD) show substantial clinical and neuropathological overlap, which limits diagnostic accuracy, and even questions the concept of distinct entities [1, 2]. On the other hand, early and accurate diagnosis of dementia is fundamental for an optimal clinical treatment. Aims: Build a topological map of disease status based on patterns of regional cerebral metabolic rate of glucose (rCMRglc). Determine the expression of disease related patterns in a cohort of…