Modulation of subthalamic nucleus local field potential power during incremental isometric force generation in Parkinson’s disease patients
E Florin, H Salimi Dafsari, C Reck, MT Barbe, A Pauls, M Maarouf, M Maarouf, V Sturm, GR Fink, L Timmermann · Klinische Neurophysiologie · 2012 · Heft 03
Bibliografische Angaben
Zusammenfassung
Local field potential (LFP) investigations of the subthalamic nucleus (STN) of patients with Parkinson’s disease have provided evidence for pathologically exaggerated oscillatory beta-band-activity (12–30 Hz) which is amenable to physiological modulation by, e.g., voluntary movement1. Previous fMRI studies in healthy controls have provided evidence for an increase of STN blood-oxygenation-level-dependent (BOLD) signal in incremental force generation tasks2. However, how neuronal activity encodes force generation and the topography of its neural correlates within the human STN remain to be elucidated. We hypothes…
