Whole-genome gene expression in nonsquamous non-small cell lung carcinoma

Background: Nonsquamous non-small cell lung carcinoma (NSCLC) in stages not suitable for surgery commonly is treated with combination chemotherapy. However, the underlying mechanisms mediating its clinical effects are yet unclear. We hypothesized that the molecular pathways triggered by chemotherapy will be reflected by distinct changes in whole-genome transcriptomic profiles of patient pre- and post-therapy. Patients and Methods: 18 patients with nonsquamous NSCLC UICC stage ≥IIIb positive for the lung tissue-specific antigen thyroid transcription factor-1 (TTF-1) were included after obtaining written informed…