Crossroads of Drug Resistance and Stem-Like Properties in Ovarian Cancer

Fragestellung: Ovarian cancer is among the most lethal gynecological malignancies, partly due to the high frequencies of recurrence. Cancer stem cells (CSC) have been implicated in drug resistance and minimal residual disease (MRD) and have also been shown to predict the risk of recurrence in ovarian cancer. In this study, we aimed at establishing a proof-of-concept model to show potential consequences of intratumoral heterogeneity in ovarian cancer. Methode: The “Vienna” variant of the human ovarian cancer cell line (A2780V) was used to isolate putative cancer stem cells (CSC) by means of side population (SP) s…