Influence of tyrosine kinase inhibitors (TKIs) on endocrinological parameters

Aims: TKIs – regardless their specifity – exert off-target effects. Currently their influence on endocrine systems – being of particular interest in growing organisms – is not clarified. We investigated growth-related parameters in juvenile rats and pediatric patients (pts) with chronic myeloid leukemia (CML) chronically exposed to TKIs. Methods: In 29 pts (n=16 male) and male rats serum testosterone (Testo), inhibin B (IB), and IGFBP3 levels were measured by ELISA. The growing animals were exposed to different TKIs (imatinib, dasatinib, bosutinib) at varying concentrations and time periods. Results: In rats com…