Increased liver stiffness – what is the influence of steatosis, necroinflammation, cholestasis and siderosis?

Aims: Elastographic measured liver stiffness (LS) correlates with hepatic fibrosis and portal pressure. Data on the impact of steatosis, siderosis, necroinflammation, and cholestasis on LS are limited. Methods: Patients with chronic liver disease underwent measurements of LS, hepatic venous pressure gradient (HVPG), and liver biopsy to assess fibrosis, necroinflammation, steatosis and cholestasis. Reliability criteria of transient elastography were defined as IQR/median ratio ≤30 with a success rate >80%. Results: 318 patients (74% male, age 48±13 years, LS 19.7±21.0 kPa, HVPG: 8.8±7.1mmHg, F1: 28/F2: 85/F3: 34/…