Wnt Signaling Pathway in Right Ventricular Remodeling

Rationale: Right ventricular (RV) remodeling comprises multiple adaptation mechanisms to increased pressure- or volume-overload, which in concert determine RV performance as well as clinical outcome in patients with pulmonary hypertension. It is believed that in the pressure-overloaded hearts a re-expression of neonatal genes, e.g. Wnt signaling molecules is triggered. Methods and Results: In our study we employed two animal models of RV remodeling: monocrotaline (MCT) model of pulmonary hypertension and pulmonary artery banding (PAB) model. To characterize global expression changes that occurred in our animal m…